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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
13.03
Human Site:
S605
Identified Species:
23.89
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
S605
P
D
L
K
N
V
G
S
S
T
G
E
K
N
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
S599
P
D
L
K
N
V
G
S
S
T
G
E
K
N
E
Dog
Lupus familis
XP_546130
745
81496
C603
P
D
L
K
N
V
G
C
N
T
G
E
K
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
S595
P
D
F
K
A
V
G
S
S
T
A
D
K
N
E
Rat
Rattus norvegicus
Q5RJQ4
350
39301
F214
F
S
C
M
Q
S
D
F
S
K
V
D
L
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
T344
N
K
E
R
N
E
R
T
S
A
A
E
T
L
R
Chicken
Gallus gallus
NP_001004767
756
82614
E617
M
N
S
E
T
M
K
E
N
G
T
N
N
G
E
Frog
Xenopus laevis
NP_001091195
710
78684
G567
V
N
T
Q
S
L
K
G
A
S
Q
T
E
T
Q
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
T243
S
L
P
S
R
F
F
T
S
M
K
A
D
F
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
P641
A
T
P
S
Y
V
R
P
S
N
L
V
Q
E
T
Honey Bee
Apis mellifera
XP_395386
868
98678
S683
D
S
C
N
S
V
D
S
H
E
D
K
N
S
K
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
T471
K
S
E
D
D
D
D
T
R
N
S
D
D
I
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
N367
N
T
V
Q
T
N
I
N
F
N
S
P
I
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
86.6
N.A.
73.3
6.6
N.A.
20
6.6
0
6.6
N.A.
13.3
13.3
0
N.A.
P-Site Similarity:
100
N.A.
100
93.3
N.A.
80
13.3
N.A.
33.3
33.3
53.3
13.3
N.A.
20
40
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
8
8
16
8
0
0
0
% A
% Cys:
0
0
16
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
31
0
8
8
8
24
0
0
0
8
24
16
0
0
% D
% Glu:
0
0
16
8
0
8
0
8
0
8
0
31
8
8
39
% E
% Phe:
8
0
8
0
0
8
8
8
8
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
31
8
0
8
24
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
8
8
8
% I
% Lys:
8
8
0
31
0
0
16
0
0
8
8
8
31
0
16
% K
% Leu:
0
8
24
0
0
8
0
0
0
0
8
0
8
24
8
% L
% Met:
8
0
0
8
0
8
0
0
0
8
0
0
0
0
0
% M
% Asn:
16
16
0
8
31
8
0
8
16
24
0
8
16
31
0
% N
% Pro:
31
0
16
0
0
0
0
8
0
0
0
8
0
0
8
% P
% Gln:
0
0
0
16
8
0
0
0
0
0
8
0
8
0
8
% Q
% Arg:
0
0
0
8
8
0
16
0
8
0
0
0
0
0
8
% R
% Ser:
8
24
8
16
16
8
0
31
54
8
16
0
0
8
0
% S
% Thr:
0
16
8
0
16
0
0
24
0
31
8
8
8
8
8
% T
% Val:
8
0
8
0
0
47
0
0
0
0
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _